![]() Mann, S.Artificial morphogen-mediated differentiation in synthetic protocells. (2) Spontaneous assembly of hemoglobin-containing cell membrane fragments on the surface of enzyme-loaded coacervate microdroplets delivers therapeutic protocells capable of high hemocompatibility, increased blood circulation times, and blood vessel vasodilation. Mann, S.Enzyme-mediated nitric oxide production in vasoactive erythrocyte membrane-enclosed coacervate protocells. (1) A nanoparticle-caged coacervate protocell model is developed which enables selective and active capture of guest objects by exogenous stimuli or endogenous enzyme reactions. Mann, S.Triggerable protocell capture in nanoparticle-caged coacervate microdroplets. Taken together, we hope that this Account will inspire new advances in membranized coacervate microdroplets and promote their application in the development of integrated protocell models and functional cytomimetic materials. Finally, we discuss the current limitations in the design and programming of membranized coacervate microdroplets, which may help to guide future directions in this emerging research area. ![]() Higher-order properties such as artificial endocytosis are achieved by using nanoparticle-caged coacervate protocell hosts that selectively and actively capture guest nano- and microscale objects by responses to exogenous stimuli or via endogenous enzyme-mediated reactions. Alternatively, therapeutic protocells with in vivo vasoactivity, high hemocompatibility, and increased blood circulation times are constructed by spontaneous assembly of hemoglobin-containing cell-membrane fragments on the surface of enzyme-loaded coacervate microdroplets. For example, immobilizing spatially segregated enzyme-loaded phospholipid-coated coacervate protocells in concentrically tubular hydrogels delivers prototissue-like bulk materials that generate nitric oxide in vitro, enabling platelet deactivation and inhibition of blood clot formation. In each case, these cytomimetic behaviors can give rise to functional microscale materials capable of promising cell-like applications. In contrast, metabolic-like endogenous reactivity, diffusive chemical signaling, and collective chemical operations occur specifically in protocell networks comprising diverse populations of membranized coacervate microdroplets. Customizable permeability is achieved by synergistic effects operating between the molecularly crowded coacervate interior and surrounding membrane. We then discuss the key cytomimetic behaviors of membranized coacervate-based model protocells. Second, we classify membrane assembly into two different approaches: (i) interfacial self-assembly by using diverse surface-active building blocks such as molecular amphiphiles (fatty acids, phospholipids, block copolymers, protein–polymer conjugates) or nano- and microscale objects (liposomes, nanoparticle surfactants, cell fragments, living cells) with appropriate wettability and (ii) coacervate droplet-to-vesicle reconfiguration by employing auxiliary surface reconstruction agents or triggering endogenous transitions ( self-membranization) under nonstoichiometric (charge mismatched) conditions. First, we briefly introduce the unusual nature of the coacervate/water interface, emphasizing the ultralow interfacial tension and broad interfacial width as physiochemical properties that require special attention in the judicious design of membranized coacervate microdroplets. ![]() In this Account, we review our recent work on diverse coacervate systems using a range of membrane building blocks and assembly processes. To address this problem, we and others have recently developed chemical-based strategies for the membranization of preformed coacervate microdroplets. Although complex coacervate microdroplets derived from associative phase separation of counter-charged electrolytes have emerged as a broad platform for the bottom-up construction of membraneless, molecularly crowded protocells, the absence of an enclosing membrane limits the construction of more sophisticated artificial cells and their use as functional cytomimetic materials. ![]()
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It's our mothers'.Ron Howard and Tom Hanks are back in this The Da Vinci Code sequel (even though the novel Angels & Demons was released first), and they again bring along Hans Zimmer and his usual band of goons to provide the score. He has served Howard well, flattered Brown more than his ham-handed writing deserves and kept things on a smart enough level to remind all comers that this isn't your father's thriller. Zimmer is an Academy Awards habitué whose nominations and/or wins include "Gladiator" with Lisa Gerrard, "The Lion King" and "Rain Man." He knows how to ride the roller coaster of Brown's populist prose and formulaic ups and downs.īut all you have to hear is the relentless build in "Rose of Arimethea," its piano tick-tock twinkling through classy chord declensions that would elude lesser composers, to know that he's aiming for something higher. 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(CNN) - Hans Zimmer's soundtrack for "The Da Vinci Code," Ron Howard's anxiously awaited cinematic gospel according to Dan Brown, is that most powerful of envoys: A model of restraint. ![]() ![]() ![]() Unavowed takes inspiration from Bioware’s RPGs in a variety of ways. You also recruit Vicki Santina (Arielle Siegel, who voices Kathy Rain in the game of the same name), a former police officer, with a very thick Staten Island accent who takes no bullshit. KayKay’s (Violet Young) a ten-year-old girl who loves teasing him and the mobile game Trollgate. You’ll recognize Logan’s abilities if you’ve played the Blackwell series, and he, too, is constantly accompanied by a spirit guide. This is someone who sees ghosts and helps them pass on to the afterlife in peace. The player and the character both have no idea about their past, which works eerily well at putting you in the character’s shoes for when you are confronted by past victims and start realizing what’s going on.Īs you progress in your journey you recruit Logan Brown (Logan Cunningham-yes, the incredible narrator from Bastion), a bestower of eternity. You go around New York City investigating different supernatural mysteries, all the while trying to piece together your past from sporadic flashes of memory. Kalash (SungWon Cho) is the head of the Unavowed, and he’s Mandana’s serious father, a blue, muscular Jinn.īecause of the possession you’ve become void touched, so you can now see what the mundane (non-magical beings) can’t, making you the perfect candidate for tracking down the demon that had possessed you and figuring out their plans. ![]() None are what they seem at first glance, Mandana (Sandra Espinoza) is a sword-wielding Jinn/human and Eli Beckett (Frank Todaro) is an accountant-turned-Fire Mage. New York City hasn’t had many supernatural crises in a hundred years, to the point where the group has dwindled to three before you join. A group of supernatural investigators and demon hunters with branches around the world. After having gone on a murderous rampage for a year, your character remembers nothing that’s happened nor can they go back to their normal life because they would be arrested immediately, so the exorcists offer them a job. Unavowed begins with your character (you choose a name, gender, and career) having a demon exorcised from their body by two people in an exhilarating introduction. The studio specializes in point and click pixel games, and while I consider several of them my favorites, Unavowed is the standout to me. ![]() The studio was created by Dave Gilbert who always designs, writes, and programs the games, and is one of my favorite Jewish creators. Wadjet Eye Games has been a favorite studio of mine since I first played Gemini Rue, a cyberpunk point and click. The mundanity of the setting combined with the fantastical characters and plot lines combine to create my ideal game. The characters are all beings that I enjoy interacting with and have knowledge about magical things that interest me. The urban setting of New York City, especially in the dark and rain, feels familiar to me even without being native to it. Certain things are like a comfort blanket to me, and this game is one. I come back to Unavowed every once in a while. Available on: Steam, itch.io, Nintendo Switch ![]() |